This guide provides practical insights for individuals and institutions on how to approach investing in pathways to employment of adolescent girls and young women in low- and middle-income (LMIC)countries. Many investors already invest in women’s economic empowerment and youth employment as a critical lever for economic development. Yet rarely are these investment portfolios designed to address the catalytic promise of longer-term economic outcomes by intentionally looking at the period of adolescence and young adulthood for females — one in eight people in the world1. Adolescent girls and young women are a significant global market that is currently underserved, especially in LMICs with young populations2. They are future employees, customers, decision-makers, influencers, suppliers and leaders — investing in their success makes economic sense and has social impact.